Structure of New Delhi metallo-ß-lactamase 1 (NDM-1).
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 10): 1160-4, 2011 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-22102018
ABSTRACT
Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-ß-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Beta-Lactamasas
/
Klebsiella pneumoniae
Idioma:
En
Revista:
Acta Crystallogr Sect F Struct Biol Cryst Commun
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido