Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic models of invasive candidiasis.
Clin Microbiol Infect
; 18(2): E20-3, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-22128831
ABSTRACT
We compared the rate and extent of anidulafungin's and fluconazole's activity in neutropenic and non-neutropenic mice with Candida albicans invasive candidiasis. In immunocompetent mice, anidulafungin significantly improved survival vs. controls and fluconazole, and significant reductions in (1â3)-ß-D-glucan and fungal burden were observed. In neutropenic animals, the highest doses of anidulafungin (5 mg/kg) and fluconazole (10 mg/kg) also improved survival and reduced fungal burden. However, there were no differences in survival between these antifungals as anidulafungin's activity was attenuated in this model. These results demonstrate that the extent of anidulafungin in vivo efficacy may be dependent on host immune status.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Candida albicans
/
Fluconazol
/
Equinocandinas
/
Candidiasis Invasiva
/
Antifúngicos
Límite:
Animals
Idioma:
En
Revista:
Clin Microbiol Infect
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos