A PLA1-2 punch regulates the Golgi complex.
Trends Cell Biol
; 22(2): 116-24, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-22130221
ABSTRACT
The mammalian Golgi complex, trans Golgi network (TGN) and ER-Golgi intermediate compartment (ERGIC) are comprised of membrane cisternae, coated vesicles and membrane tubules, all of which contribute to membrane trafficking and maintenance of their unique architectures. Recently, a new cast of players was discovered to regulate the Golgi and ERGIC four unrelated cytoplasmic phospholipase A (PLA) enzymes, cPLA(2)α (GIVA cPLA(2)), PAFAH Ib (GVIII PLA(2)), iPLA(2)-ß (GVIA-2 iPLA(2)) and iPLA(1)γ. These ubiquitously expressed enzymes regulate membrane trafficking from specific Golgi subcompartments, although there is evidence for some functional redundancy between PAFAH Ib and cPLA(2)α. Three of these enzymes, PAFAH Ib, cPLA(2)α and iPLA(2)-ß, exert effects on Golgi structure and function by inducing the formation of membrane tubules. We review our current understanding of how PLA enzymes regulate Golgi and ERGIC morphology and function.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fosfolipasas A2
/
Aparato de Golgi
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cell Biol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos