An exploratory study to determine the association between assessed facial skin aging and plasma isoprostane levels in middle-aged Japanese women.
Dermatol Surg
; 38(3): 462-70, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22141590
ABSTRACT
BACKGROUND:
One of the central mechanisms of aging is hypothesized to be oxidative stress. Quantification of oxidative stress in human organ systems has been difficult. One of the best methods is using plasma isoprostane levels, which have been shown to reflect oxidative stress in multiple nondermatologic organ systems.OBJECTIVE:
To determine whether severity of aging of human skin is associated with plasma isoprostane levels, specifically prostaglandin F2a (PGF2a) and 8-iso-PGF2a while controlling for covariates such as body mass index, ultraviolet light exposure, diet, medication, supplement use, and stress levels. METHODS AND MATERIALS Facial skin aging assessments performed by four blinded dermatologists were correlated with plasma isoprostane levels in 46 healthy, nonsmoking Japanese women aged 45 to 60.RESULTS:
Individuals whose assessed skin age exceeded chronological age had mean plasma isoprostane levels of PGF2a and 8-iso-PGF2a that were higher than those whose skin age was assessed to be less than chronological age (p = .001 and .001, respectively). These results remained statistically significant when adjusted for confounding variables (8-iso-PGF2a, p = .02; PGF2a, p = .03).CONCLUSIONS:
Plasma isoprostanes as markers of accelerated aging of the skin merit further study.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Envejecimiento de la Piel
/
Isoprostanos
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Dermatol Surg
Asunto de la revista:
DERMATOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos