Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study.
J Infect Dis
; 205(1): 13-9, 2012 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-22170954
ABSTRACT
BACKGROUND:
Statins may have anti-inflammatory and immunomodulatory effects that could reduce the risk of mortality from influenza virus infections.METHODS:
The Centers for Disease Control and Prevention's Emerging Infections Program conducts active surveillance for persons hospitalized with laboratory-confirmed influenza in 59 counties in 10 states. We analyzed data for hospitalized adults during the 2007-2008 influenza season to evaluate the association between receiving statins and influenza-related death.RESULTS:
We identified 3043 patients hospitalized with laboratory-confirmed influenza, of whom 1013 (33.3%) received statins and 151 (5.0%) died within 30 days of their influenza test. Patients who received statins were more likely to be older, male, and white; to suffer from cardiovascular, metabolic, renal, and chronic lung disease; and to have been vaccinated against influenza that season. In a multivariable logistic regression model, administration of statins prior to or during hospitalization was associated with a protective odds of death (adjusted odds ratio, 0.59 [95% confidence interval, .38-.92]) when adjusting for age; race; cardiovascular, lung, and renal disease; influenza vaccination; and antiviral administration.CONCLUSIONS:
Statin use may be associated with reduced mortality in patients hospitalized with influenza.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Gripe Humana
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Infect Dis
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos