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Infection with Cryptosporidium hominis provides incomplete protection of the host against Cryptosporidium parvum.
Sheoran, Abhineet; Wiffin, Anthony; Widmer, Giovanni; Singh, Pradeep; Tzipori, Saul.
Afiliación
  • Sheoran A; Department of Biomedical Sciences, Tufts University, North Grafton, MA, USA. abhineet.sheoran@tufts.edu
J Infect Dis ; 205(6): 1019-23, 2012 Mar 15.
Article en En | MEDLINE | ID: mdl-22279124
Cryptosporidium hominis and Cryptosporidium parvum, which infect humans equally, are genetically/antigenically almost identical. It remains unclear, however, whether infection with C. hominis protects against C. parvum. Gnotobiotic piglets were used to investigate cross-protection. After ≥3 days of recovery from C. hominis infection, the piglets were completely protected against subsequent challenge with C. hominis but only partially against challenge with C. parvum, as compared with age-matched control animals challenged with either species. In conclusion, C. hominis-specific immunity was sufficient to completely protect against challenge with the same species but insufficient to provide the same level of protection against C. parvum.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cryptosporidium parvum / Criptosporidiosis / Cryptosporidium / Protección Cruzada Límite: Animals / Child / Humans Idioma: En Revista: J Infect Dis Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cryptosporidium parvum / Criptosporidiosis / Cryptosporidium / Protección Cruzada Límite: Animals / Child / Humans Idioma: En Revista: J Infect Dis Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos