A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer.
Cell Stem Cell
; 10(2): 183-97, 2012 Feb 03.
Article
en En
| MEDLINE
| ID: mdl-22305568
ABSTRACT
Gene expression signatures relating mammary stem cell populations to breast cancers have focused on adult tissue. Here, we identify, isolate, and characterize the fetal mammary stem cell (fMaSC) state since the invasive and proliferative processes of mammogenesis resemble phases of cancer progression. fMaSC frequency peaks late in embryogenesis, enabling more extensive stem cell purification than achieved with adult tissue. fMaSCs are self-renewing, multipotent, and coexpress multiple mammary lineage markers. Gene expression, transplantation, and in vitro analyses reveal putative autocrine and paracrine regulatory mechanisms, including ErbB and FGF signaling pathways impinging on fMaSC growth. Expression profiles from fMaSCs and associated stroma exhibit significant similarities to basal-like and Her2+ intrinsic breast cancer subtypes. Our results reveal links between development and cancer and provide resources to identify new candidates for diagnosis, prognosis, and therapy.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células Madre Neoplásicas
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Neoplasias de la Mama
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Carcinoma Basocelular
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Células Madre Pluripotentes
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Glándulas Mamarias Humanas
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Células Madre Embrionarias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Cell Stem Cell
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos