Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis.

Chen, Li-Yin; Chen, Ih-Sheng; Peng, Chien-Fang

Chen, Li-Yin; Chen, Ih-Sheng; Peng, Chien-Fang.

Afiliación

Chen LY; Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 71710, Taiwan.
Chen IS; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Peng CF; Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Int J Mol Sci ; 13(1): 1029-1038, 2012.

Article en En | MEDLINE | ID: mdl-22312302

ABSTRACT

ABSTRACT

Three new biflavonoids, wikstaiwanones A-C (1-3), along with four known compounds (4-7) were isolated from the stems of Wikstroemia taiwanensis (Thymelaeaceae). Their structures were elucidated by spectroscopic analysis. Compounds 4 and 5 showed antitubercular activity against Mycobacterium tuberculosis with MIC values of 15 µg/mL, respectively.

Asunto(s)

Antituberculosos/química; Biflavonoides/química; Tallos de la Planta/química; Wikstroemia/química; Antituberculosos/farmacología; Biflavonoides/farmacología; Espectroscopía de Resonancia Magnética; Pruebas de Sensibilidad Microbiana; Conformación Molecular; Mycobacterium tuberculosis/efectos de los fármacos; Tallos de la Planta/metabolismo; Wikstroemia/metabolismo

Palabras clave

Thymelaeaceae; Wikstroemia taiwanensis; antitubercular activity; biflavonoid; stem

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tallos de la Planta / Wikstroemia / Biflavonoides / Antituberculosos Idioma: En Revista: Int J Mol Sci Año: 2012 Tipo del documento: Article País de afiliación: Taiwán

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