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Does HLA-B*2706 protect against ankylosing spondylitis? A meta-analysis.
Van Gaalen, Floris Alexander.
Afiliación
  • Van Gaalen FA; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. f.a.van_gaalen@lumc.nl
Int J Rheum Dis ; 15(1): 8-12, 2012 Feb.
Article en En | MEDLINE | ID: mdl-22324941
The human leukocyte antigen (HLA)-B*2706 is a relatively rare subtype of HLA-B27. In contrast to most HLA-B27 subtypes, some studies have reported HLA-B*2706 to be protective against ankylosing spondylitis (AS). A systematic review and a meta-analysis of available studies was performed to investigate the association of HLA-B*2706 with AS. After literature review a random effect meta-analysis was performed. No studies were found comparing the frequency of HLA-B*2706 in AS patients and controls. Meta-analysis of seven studies using HLA-B27-positive AS patients and controls showed a protective effect of HLA-B*2706 on development of AS in HLA-B27 individuals (odds ratio = 0.128, 95% CI = 0.043-0.378, P < 0.001). The results of the meta-analysis of HLA-B*2706 in HLA-B27-positive patients and controls is preliminary evidence of a protective effect of HLA-B*2706 against AS in the population. There is a clear need for additional studies on HLA-B*2706 in AS. Due to the fact that HLA-B*2706 is more or less restricted to Southeast Asia, researchers in this part of the world may have an essential role in performing these studies.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Antígeno HLA-B27 Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Espondilitis Anquilosante / Antígeno HLA-B27 Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Int J Rheum Dis Asunto de la revista: REUMATOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Países Bajos