A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7/IL-24 expression.
Br J Cancer
; 106(12): 1976-9, 2012 Jun 05.
Article
en En
| MEDLINE
| ID: mdl-22588557
ABSTRACT
BACKGROUND:
Translocated in liposarcoma-CCAAT/enhancer binding protein homologous protein (TLS-CHOP) (also known as FUS-DDIT3) chimeric oncoprotein is found in the majority of human myxoid liposarcoma (MLS), but its molecular function remains unclear.METHODS:
We knockdowned TLS-CHOP expression in MLS-derived cell lines by a specific small interfering RNA, and analysed the gene expression profiles with microarray.RESULTS:
TLS-CHOP knockdown inhibited growth of MLS cells, and induced an anticancer cytokine, melanoma differentiation-associated gene 7 (MDA-7)/interleukin-24 (IL-24) expression. However, double knockdown of TLS-CHOP and MDA-7/IL-24 did not inhibit MLS cell growth.CONCLUSION:
Repression of MDA-7/IL-24 expression by TLS-CHOP is required for MLS tumour growth, and TLS-CHOP may become a promising therapeutic target for MLS treatment.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Fusión Oncogénica
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Interleucinas
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Liposarcoma Mixoide
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Proteína FUS de Unión a ARN
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Factor de Transcripción CHOP
Límite:
Humans
Idioma:
En
Revista:
Br J Cancer
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón