Phosphorylation puts the pRb tumor suppressor into shape.
Genes Dev
; 26(11): 1128-30, 2012 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-22661226
ABSTRACT
In this issue of Genes & Development, Burke and colleagues (pp. 1156-1166) describe how the structure of retinoblastoma protein (pRb) is altered by phosphorylation at T373 or S608. These modifications cause specific conformational changes and alter pRb's interaction with E2F via two distinct mechanisms. The structures suggest that the panel of phosphorylation sites represents a versatile set of tools that are used to sculpt pRb in precise, but very different, ways.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ciclo Celular
/
Proteína de Retinoblastoma
Idioma:
En
Revista:
Genes Dev
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos