Solid dispersions in pharmaceutical technology. Part I. Classification and methods to obtain solid dispersions.
Polim Med
; 42(1): 17-27, 2012.
Article
en En
| MEDLINE
| ID: mdl-22783729
ABSTRACT
There are many methods to increase solubility of a substance. These include, inter alia, preparation of solid dispersions, i.e. eutectic mixtures, solid solutions, glassy solutions and suspensions. When compared to the individual constituents prior to dispersion formation solid dispersion components are better soluble in water. Therefore, solid solutions became one of the most promising ways to modify solubility, ensuring improved bioavailability and consequently therapeutic efficacy of a substance. In this part of the publication solid dispersions were classified and described in regard to their properties and preparation methods, i.e. melting method, melt evaporation and melt extrusion methods, lyophilisation technique, melt agglomeration process as well as SCF technology and electrospinning.
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Bases de datos:
MEDLINE
Asunto principal:
Química Farmacéutica
Idioma:
En
Revista:
Polim Med
Año:
2012
Tipo del documento:
Article
País de afiliación:
Polonia