Surface-modified gemcitabine with mucoadhesive polymer for oral delivery.
J Microencapsul
; 29(5): 487-96, 2012.
Article
en En
| MEDLINE
| ID: mdl-22783823
ABSTRACT
Gemcitabine microparticles were prepared using chitosan, polyethylene oxide or carbopol as the mucoadhesive polymer and eudragit L100-55 as the enteric polymer by a double emulsion method. The particle size and zeta potential changed from 1338.3 ± 254.1 nm to 2459.4 ± 103.6 nm and -5.16 ± 1.62 mV to 2.84 ± 0.65 mV, respectively, with increasing chitosan to gemcitabine weight ratio from 0.25 to 1. The gemcitabine-loaded microparticles without mucoadhesive polymer (F50) showed the particle size and zeta potential of 671.3 ± 58.3 nm and - 16.7 ± 1.82 mV, respectively. The cellular uptake of gemcitabine into Caco-2 cells from gemcitabine-loaded microparticles with chitosan increased with increasing incubation time in Caco-2 cells compared to that of gemcitabine-loaded microparticles with polyethylene oxide or carbopol, suggesting that chitosan might be the optimal mucoadhesive polymer. Gemcitabine microparticles will be tested to identify whether the oral absorption could be increased in the future.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polietilenglicoles
/
Polivinilos
/
Portadores de Fármacos
/
Desoxicitidina
/
Quitosano
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Antimetabolitos Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
J Microencapsul
Asunto de la revista:
FARMACIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Corea del Sur