Hereditary hemochromatosis restores the virulence of plague vaccine strains.
J Infect Dis
; 206(7): 1050-8, 2012 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-22896664
ABSTRACT
Nonpigmented Yersinia pestis (pgm) strains are defective in scavenging host iron and have been used in live-attenuated vaccines to combat plague epidemics. Recently, a Y. pestis pgm strain was isolated from a researcher with hereditary hemochromatosis who died from laboratory-acquired plague. We used hemojuvelin-knockout (Hjv(-/-)) mice to examine whether iron-storage disease restores the virulence defects of nonpigmented Y. pestis. Unlike wild-type mice, Hjv(-/-) mice developed lethal plague when challenged with Y. pestis pgm strains. Immunization of Hjv(-/-) mice with a subunit vaccine that blocks Y. pestis type III secretion generated protection against plague. Thus, individuals with hereditary hemochromatosis may be protected with subunit vaccines but should not be exposed to live-attenuated plague vaccines.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Peste
/
Yersinia pestis
/
Vacuna contra la Peste
/
Hemocromatosis
Límite:
Animals
Idioma:
En
Revista:
J Infect Dis
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos