Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism.
Chem Biol
; 19(8): 1020-7, 2012 Aug 24.
Article
en En
| MEDLINE
| ID: mdl-22921069
ABSTRACT
Bacterially produced secondary metabolites are used as antibiotics, anticancer drugs, and for many other medicinal applications. The mechanisms that limit the production of these molecules in the laboratory are not well understood, and this has impeded the discovery of many important compounds. We have identified small molecules that remodel the yields of secondary metabolites in many actinomycetes and show that one set of these molecules does so by inhibiting fatty acid biosynthesis. This demonstrates a particularly intimate relationship between this primary metabolic pathway and secondary metabolism and suggests an approach to enhance the yields of metabolites for discovery and biochemical characterization.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Actinobacteria
/
Ácidos Grasos
Idioma:
En
Revista:
Chem Biol
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Canadá