Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis.
Arch Virol
; 158(1): 165-72, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23053518
ABSTRACT
The full-length genome sequence of a genotype 4 strain of Hepatitis E virus (HEV) (CHN-NJ-H2011) from a patient (in Nanjing, China) with liver failure has been determined. Phylogenetic analysis showed that CHN-NJ-H2011 belongs to genotype 4, subtype 4h. Comparative sequence analysis carried out on a 301-bp fragment of ORF2 showed that CHN-NJ-H2011 shares high nucleotide sequence identity (94.3-94.7 %) with porcine viruses (ch-shsw1 and Ch-estw2) isolated in the same geographical region, pointing to the strong possibility of zoonotic transmission of HEV genotype 4. A broader comparison with other genotype 4 isolates revealed 12 unique amino acid substitutions in ORF1 and three in ORF2 that might serve as signatures of disease severity for genotype 4 HEV infection.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Virus de la Hepatitis E
/
Fallo Hepático
Tipo de estudio:
Etiology_studies
Límite:
Aged
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Arch Virol
Año:
2013
Tipo del documento:
Article
País de afiliación:
China