Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model.
Am J Obstet Gynecol
; 207(6): 475.e1-475.e14, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-23111115
ABSTRACT
OBJECTIVE:
We assessed the efficacy of a maternal multidose azithromycin (AZI) regimen, with and without antiinflammatory agents to delay preterm birth and to mitigate fetal lung injury associated with Ureaplasma parvum intraamniotic infection. STUDYDESIGN:
Long-term catheterized rhesus monkeys (n = 16) received intraamniotic inoculation of U parvum (10(7) colony-forming U/mL, serovar 1). After contraction onset, rhesus monkeys received no treatment (n = 6); AZI (12.5 mg/kg, every 12 h, intravenous for 10 days; n = 5); or AZI plus dexamethasone and indomethacin (n = 5). Outcomes included amniotic fluid proinflammatory mediators, U parvum cultures and polymerase chain reaction, AZI pharmacokinetics, and the extent of fetal lung inflammation.RESULTS:
Maternal AZI therapy eradicated U parvum intraamniotic infection from the amniotic fluid within 4 days. Placenta and fetal tissues were 90% culture negative at delivery. AZI therapy significantly delayed preterm delivery and prevented advanced fetal lung injury, although residual acute chorioamnionitis persisted.CONCLUSION:
Specific maternal antibiotic therapy can eradicate U parvum from the amniotic fluid and key fetal organs, with subsequent prolongation of pregnancy, which provides a therapeutic window of opportunity to effectively reduce the severity of fetal lung injury.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ureaplasma
/
Corioamnionitis
/
Infecciones por Ureaplasma
/
Azitromicina
/
Nacimiento Prematuro
/
Lesión Pulmonar
/
Antibacterianos
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos