Discrete nanomolecular polyhedral borane scaffold supporting multiple gadolinium(III) complexes as a high performance MRI contrast agent.
Inorg Chem
; 52(4): 1694-700, 2013 Feb 18.
Article
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| MEDLINE
| ID: mdl-23126285
ABSTRACT
An icosahedral closo-B(12)(2-) scaffold supports 12 copies of Gd(3+)-chelate held in close proximity with each other by suitable linkers which employ azide-alkyne click chemistry. This design is the first member of a new class of polyfunctional MRI contrast agents carrying a high payload of Gd(3+)-chelate in a sterically constrained configuration. The resulting contrast agent shows higher relaxivity values at high magnetic fields. MRI contrast agents currently in use are not as effective in this regard, presumably due to a lack of steric constraint of gadolinium centers and lower water exchange rates. In vivo MRI studies in mice show excellent contrast enhancement even at one-seventh of the safe clinical dose (0.04 mmol Gd/kg) for up to a 1 h exposure.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
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Neoplasias de la Próstata
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Imagen por Resonancia Magnética
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Medios de Contraste
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Neoplasias Experimentales
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Inorg Chem
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos