Amino acid exchanges in the putative nuclear export signal of adenovirus type 5 L4-100K severely reduce viral progeny due to effects on hexon biogenesis.
J Virol
; 87(3): 1893-8, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23175361
The adenovirus type 5 nonstructural L4-100K protein is indispensable for efficient lytic infection. During the late phase, L4-100K promotes selective translation of viral late transcripts and mediates the trimerization of the major capsid protein hexon. In the present study, the role of a potential nuclear export signal in L4-100K was investigated. Intriguingly, amino acid substitutions in this sequence resulted in severely diminished progeny virus production, seemingly by precluding proper hexon biogenesis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Adenovirus Humanos
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Proteínas no Estructurales Virales
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Sustitución de Aminoácidos
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Proteínas de la Cápside
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Señales de Exportación Nuclear
Idioma:
En
Revista:
J Virol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania