Diterpenoids and sesquiterpenoids from the twigs and leaves of Illicium majus.
Planta Med
; 79(2): 142-9, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23250809
ABSTRACT
Four new abietane diterpenes (1-4) and two new cycloparvifloralone-type sesquiterpenoids (5-6) have been isolated from the twigs and leaves of Illicium majus, together with three known sesquiterpenoids and five known diterpenoids. Their structures were determined by spectroscopic analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 2 is confirmed by Snatzke's method, observing the induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 2 exihibited significant anti-inflammatory activity with an IC50 value of 0.26 ± 0.03 µM, while compounds 10, 11, and 13 showed good anti-inflammatory activities with IC50 values ranging from 1.94 ± 0.56 to 2.60 ± 0.48 µM.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
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Illicium
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Diterpenos
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Antiinflamatorios
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Planta Med
Año:
2013
Tipo del documento:
Article