BMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause.
BMC Cell Biol
; 14: 18, 2013 Mar 19.
Article
en En
| MEDLINE
| ID: mdl-23510080
ABSTRACT
BACKGROUND:
The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats.RESULTS:
Cisplatin increased GC apoptosis from 0.59% to 13.04% in the control and cisplatin treatment groups, respectively, which was significantly reduced upon co-culture with BMSCs to 4.84%. Cisplatin treatment increased p21 and bax and decreased c-myc mRNA expression, which was reversed upon co-culture with BMSCs. As compared to young rats, increased apoptosis was observed in the perimenopausal rats (P < 0.001). After 3 months, the apoptosis rate in the BMSC group was significantly lower than that of the control group (P = 0.007).CONCLUSIONS:
BMSC therapy may protect against GC apoptosis induced by cisplatin and perimenopause. Further studies are necessary to evaluate therapeutic efficacy of BMSCs.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células de la Médula Ósea
/
Cisplatino
/
Técnicas de Cocultivo
/
Trasplante de Células Madre Mesenquimatosas
/
Perimenopausia
/
Inhibidor p21 de las Quinasas Dependientes de la Ciclina
/
Células Madre Mesenquimatosas
/
Células de la Granulosa
Límite:
Animals
Idioma:
En
Revista:
BMC Cell Biol
Año:
2013
Tipo del documento:
Article