Novel instrumentation to determine peel force in vivo and preliminary studies with adhesive skin barriers.
Skin Res Technol
; 19(4): 398-404, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23527472
ABSTRACT
BACKGROUND/PURPOSE:
Adhesive barriers secure medical devices to skin. Laboratory adhesion models are not predictive of in vivo performance. The objectives of these studies were to validate a novel peel force device, and to investigate relationships between barrier formulations, barrier width, subjective discomfort during barrier removal, and substrates.METHODS:
Three hydrocolloid barrier formulations in three widths were adhered to ethylene/methyl acrylate film (EMA), VITRO-SKIN(®) and human abdominal skin. Peel force was measured using a MTS Insight™ and a cyberDERM Inc. Mini Peel Tester (CMPT). Subjects reported their discomfort.RESULTS:
Peel forces were highly correlated between devices and highly dependent on substrate. Data suggested a weak direct association between peel force in vivo and discomfort. The 0.5â³-wide barriers had the most precise peel forces measurements in vivo. A weak negative relationship between normalized peel force and barrier width on human skin was found. There was a strong positive relationship between peel force in vivo and on EMA, whereas no correlation was observed with VITRO-SKIN(®).CONCLUSION:
The CMPT correlates with a standard instrument and can advantageously investigate adhesion in vivo. Barrier width and substrate impact the reliability and predictability of peel force measurements.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piel
/
Pruebas Cutáneas
/
Cinta Quirúrgica
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Skin Res Technol
Asunto de la revista:
DERMATOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos