Highly enantioselective hydrogenation of 2,4-diaryl-1,5-benzodiazepines catalyzed by dendritic phosphinooxazoline iridium complexes.

ABSTRACT

A PHOX with arms A series of dendrimers with Ir phosphinooxazoline (PHOX) cores were designed and synthesized and found to be highly effective and recoverable catalysts for asymmetric hydrogenation of 2,4-diaryl-1,5-benzodiazepines. An obvious positive dendritic effect on reactivity was observed, leading to chiral nitrogen-containing heterocycles with excellent enantioselectivities.