Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.
Immunity
; 38(4): 831-44, 2013 Apr 18.
Article
en En
| MEDLINE
| ID: mdl-23601689
ABSTRACT
Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Orthomyxoviridae
/
Infecciones Neumocócicas
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Streptococcus pneumoniae
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Vacunas contra la Influenza
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Interferones
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Vacunas Neumococicas
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Gripe Humana
Tipo de estudio:
Qualitative_research
Límite:
Humans
Idioma:
En
Revista:
Immunity
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos