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Long-term safety of anti-TNF adalimumab in HBc antibody-positive psoriatic arthritis patients: a retrospective case series of 8 patients.
Laurenti, R; Giovannangeli, F; Gubinelli, E; Viviano, M T; Errico, A; Leoni, L; Ballanti, E; Migliore, A.
Afiliación
  • Laurenti R; Unità di Reumatologia, Istituto Dermopatico dell'Immacolata-IRCCS, Via Monti di Creta 104, 00165 Rome, Italy.
Clin Dev Immunol ; 2013: 410521, 2013.
Article en En | MEDLINE | ID: mdl-23606869
ABSTRACT
Immunosuppressive drugs commonly used in the treatment of psoriatic arthritis make patients more susceptible to viral, bacterial, and fungal infections because of their mechanism of action. They not only increase the risk of new infections but also act altering the natural course of preexisting infections. While numerous data regarding the reactivation of tuberculosis infection are available in the literature, poor information about the risk of reactivation or exacerbation of hepatitis viruses B and C infections during treatment with biologics has been reported. Furthermore, reported series with biological therapy included short periods of followup, and therefore, they are not adequate to verify the risk of reactivation in the long-term treatment. Our study evaluated patients with a history of hepatitis B and psoriatic arthritis treated with adalimumab and monitored up to six years. During the observation period, treatment was effective and well tolerated in all patients, and liver function tests and viral load levels remained unchanged.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Artritis Psoriásica / Factor de Necrosis Tumoral alfa / Anticuerpos contra la Hepatitis C / Anticuerpos Monoclonales Humanizados / Anticuerpos contra la Hepatitis B Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Dev Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Artritis Psoriásica / Factor de Necrosis Tumoral alfa / Anticuerpos contra la Hepatitis C / Anticuerpos Monoclonales Humanizados / Anticuerpos contra la Hepatitis B Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Dev Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Italia