Influenza H3N2 variant viruses with pandemic potential: preventing catastrophe in remote and isolated Canadian communities.
Prev Med
; 57(6): 910-3, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23628518
OBJECTIVE: To evaluate the impact of age-specific cross-reactive antibody protection levels on the outcomes of a pandemic outbreak of new variants of H3N2 influenza A viruses (H3N2v). METHODS: We calibrated a previously validated agent-based model of human-to-human transmission of influenza viruses to project the outcomes of various protection levels in a remote and isolated Canadian community, when demographics are drawn from the Statistics Canada census data. We then compared the outcomes with a scenario in which demographic variables were shifted to resemble an urban structure. This comparative evaluation was conducted using in-silico computer simulations, where the epidemiological data were drawn from relevant estimates in published literature. RESULTS: Simulations, using estimates of transmissibility for the 2009 H1N1 pandemic strain in the study population, show that the epidemic size is primarily affected by the cross-reactive protection levels of young children. A lower number of secondary infections at the early stages of an outbreak does not necessarily correspond to a lower epidemic size. CONCLUSIONS: Demographic variables could play a significant role in determining the outcomes of an outbreak. The findings strongly suggest that, when an H3N2v-specific vaccine becomes available, children below the age of 17 should be prioritized for vaccination. This prioritization is essential in population settings with a low average age, including aboriginal communities in northern latitudes.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Gripe Humana
/
Subtipo H3N2 del Virus de la Influenza A
/
Pandemias
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Middle aged
/
Newborn
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Prev Med
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá