Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.
Viruses
; 5(5): 1292-324, 2013 May 23.
Article
en En
| MEDLINE
| ID: mdl-23698400
ABSTRACT
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review the evidence surrounding pathogenesis of the hepatitis C infection regarding lipoprotein engagement, cholesterol and triglyceride regulation, and the molecular mechanisms underlying these effects.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Colesterol
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Hepatitis C
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Hepacivirus
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Ensamble de Virus
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Internalización del Virus
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Liberación del Virus
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Lipoproteínas
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Viruses
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia