GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling.
Nat Immunol
; 14(7): 714-22, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23708251
ABSTRACT
GATA-3 controls T helper type 2 (TH2) differentiation. However, whether GATA-3 regulates the function of mature T cells beyond TH2 determination remains poorly understood. We found that signaling via the T cell antigen receptor (TCR) and cytokine stimulation promoted GATA-3 expression in CD8(+) T cells, which controlled cell proliferation. Although GATA-3-deficient CD8(+) T cells were generated, their peripheral maintenance was impaired, with lower expression of the receptor for interleukin 7 (IL-7R). GATA-3-deficient T cells had defective responses to viral infection and alloantigen. The proto-oncoprotein c-Myc was a critical target of GATA-3 in promoting T cell proliferation. Our study thus demonstrates an essential role for GATA-3 in controlling the maintenance and proliferation of T cells and provides insight into immunoregulation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
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Receptores de Antígenos de Linfocitos T
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Proteínas Proto-Oncogénicas c-myc
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Linfocitos T CD8-positivos
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Receptores de Interleucina-7
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Factor de Transcripción GATA3
Límite:
Animals
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos