Characterization of AntB, a promiscuous acyltransferase involved in antimycin biosynthesis.
Org Lett
; 15(13): 3396-9, 2013 Jul 05.
Article
en En
| MEDLINE
| ID: mdl-23772837
ABSTRACT
The in vivo and in vitro characterization of AntB, a dedicated acyltransferase encoded in the antimycin biosynthetic gene cluster, which catalyzes the C-8 acyloxy formation is reported. It is demonstrated that AntB has broad substrate specificity toward both the acyl substrate and the acyl carrier and produces more antimycin analogues with varying C-8 acyloxy moieties.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Aciltransferasas
/
Escherichia coli
/
Antimicina A
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos