Review of vasodilators in acute decompensated heart failure: the old and the new.
J Card Fail
; 19(7): 478-93, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23834924
ABSTRACT
Despite substantial improvements in treatment for chronic heart failure, morbidity and mortality for acute decompensated heart failure (ADHF) remain high. Treatment of ADHF is focused on controlling symptoms rather than improving long-term outcomes. The vasodilators nitroglycerin (NTG) and sodium nitroprusside (SNP) have been used in ADHF for decades, but, since the development of nesiritide 10 years ago, interest in new vasodilators has grown. Therapies that improve not only hemodynamics and symptoms but also long-term outcomes are in high demand, and numerous new vasodilatory agents have been investigated, including various natriuretic peptides, soluble guanylyl cyclase agents, renin-angiotensin-aldosterone system-modifying agents, and others. A review of the literature shows that few of them rise to the challenge set by NTG and SNP.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vasodilatadores
/
Insuficiencia Cardíaca
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Card Fail
Asunto de la revista:
CARDIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos