Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases.
Bioorg Med Chem
; 21(18): 5707-24, 2013 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-23920481
Palabras clave
9-BBN; 9-borabicyclo[3.1.1.]nonane Boc tert-butyloxycarbonyl; AGC; ATP; CAMK; Cbz; DFG; DIBAL-H; HA; Kinase inhibitor; LE; PKA; PKB; Protein kinase; RCM; S(N)Ar; Selectivity; Spirocycle; TK; adenosine triphosphate; aspartatephenylalanineglycine sequence; benzyloxycarbonyl; calcium/calmodulin-dependent kinases; diisobutylaluminium hydride; heavy atom; ligand efficiency; nucleophilic aromatic substitution; protein kinase A; protein kinase B; protein kinases A G and C; ring-closing metathesis; tyrosine kinase
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos de Espiro
/
Compuestos Aza
/
Inhibidores de Proteínas Quinasas
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Reino Unido