Liquid chromatography-tandem mass spectrometry method as the golden standard for therapeutic drug monitoring in renal transplant.
J Pharm Biomed Anal
; 86: 123-6, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23995754
ABSTRACT
Kidney transplanted patients need immunosuppressant therapies. Therapeutic drug monitoring approaches produce the optimal clinical outcome is still under debate. This review details strength and limits of methods available immunoassay and chromatography-based. Liquid chromatography with mass spectrometry detection is a major breakthrough in therapeutic drug monitoring of immunosuppressive agents and is considered as the method of choice in therapeutic drug monitoring (TDM) of immunosuppressants. Despite the initial high cost for the instrumentation, HPLC-MS is more cost effective than microparticle enzyme immunoassay. The main important features of LC-MS/MS methodology for immunosuppressive drugs are the shortened analysis time, an increased throughput, higher selectivity, specificity, and sensitivity, and low cost of analysis.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
/
Monitoreo de Drogas
/
Espectrometría de Masas en Tándem
/
Inmunosupresores
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia