In vivo strategies for drug discovery in myotonic dystrophy disorders.
Drug Discov Today Technol
; 10(1): e97-102, 2013.
Article
en En
| MEDLINE
| ID: mdl-24050236
ABSTRACT
Myotonic dystrophy (DM) is a complex neuromuscular genetic disease for which there is currently no valid therapy. The recent development of non-mammal animal models opened up the possibility of performing drug discovery in vivo, using as screening readout phenotypes with underlying molecular parallels to the disease. In this review we discuss the state of the art technologies already used in large scale drug screening and provide guidance for further development of novel technologies.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Descubrimiento de Drogas
/
Distrofia Miotónica
Tipo de estudio:
Guideline
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Discov Today Technol
Año:
2013
Tipo del documento:
Article