Impact of hemodialysis on exhaled volatile organic compounds in end-stage renal disease: a pilot study.
Nanomedicine (Lond)
; 9(7): 1035-45, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24066923
ABSTRACT
AIM:
To demonstrate the feasibility of nanomaterial-based sensors for identifying patterns of exhaled volatile organic compound of end-stage renal disease (ESRD) and study the impact of hemodialysis (HD) on these patterns. PATIENTS &METHODS:
Exhaled breath samples were collected from a group of 37 volunteers (26 ESRD HD patients; 11 healthy controls); a third of the samples were randomly blinded for determining the sensitivity/specificity of the method. Discriminant function analysis was used to build a model for discriminating ESRD patients and healthy controls (classification accuracy for blind samples 80%), based on the signals of the nanomaterial sensors. RESULTS &CONCLUSION:
The breath pattern of the ESRD patients approached the healthy pattern during the HD treatment, without reaching it completely. Gas chromatography/mass spectrometry identified four volatile organic compounds as potential ESRD biomarkers. Although this pilot study has yielded encouraging results, additional large-scale clinical studies are required to develop a fast, noninvasive breath test for monitoring HD adequacy in real time.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Diálisis Renal
/
Compuestos Orgánicos Volátiles
/
Fallo Renal Crónico
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Israel