Maintenance of epigenetic information: a noncoding RNA perspective.
Chromosome Res
; 21(6-7): 615-25, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-24190518
ABSTRACT
Along the lines of established players like chromatin modifiers and transcription factors, noncoding RNA (ncRNA) are now widely accepted as one of the key regulatory molecules in epigenetic regulation of transcription. With increasing evidence of ncRNAs in the establishment of gene silencing through their ability to interact with major chromatin modifiers, in the current review, we discuss their prospective role in the area of inheritance and maintenance of these established silenced states which can be reversible or irreversible in nature. In addition, we attempt to understand and speculate how these RNA dependent or independent maintenance mechanisms differ between each other in a developmental stage, tissue, and gene-specific manner in different biological contexts by utilizing known/unknown regulatory factors.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Transcripción Genética
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Impresión Genómica
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ARN no Traducido
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Epigénesis Genética
Límite:
Humans
Idioma:
En
Revista:
Chromosome Res
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2013
Tipo del documento:
Article
País de afiliación:
Suecia