Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey.
J Infect Dis
; 209(6): 837-44, 2014 Mar.
Article
en En
| MEDLINE
| ID: mdl-24253286
ABSTRACT
BACKGROUND:
Herpesviruses have been linked to cognitive impairment in older individuals but little is known about the association in the general US population.METHODS:
We determined whether cytomegalovirus (CMV) and herpes simplex virus 1 (HSV-1) seropositivity were associated with cognitive impairment among children (aged 6-16 years) and adults aged 20-59 or ≥60 years, using data from the National Health and Nutrition Examination Survey (NHANES) III. Linear and logistic regression models were used to examine the associations between pathogen seropositivity and cognitive impairment.RESULTS:
Among children, HSV-1 seropositivity was associated with lower reading and spatial reasoning test scores (ß, -0.69; 95% confidence interval [CI], -1.18 to -.21 and ß, -0.82; 95% CI, -1.29 to -.36, respectively). Among middle-aged adults, HSV-1 and CMV seropositivity were associated with impaired coding speed (odds ratio [OR], 1.54; 95% CI, 1.13-2.11, and OR, 1.41; 95% CI, 1.09-1.82, respectively). CMV seropositivity was also associated with impaired learning and recall (OR, 1.43; 95% CI, 1.14-1.80). Among older adults, HSV-1 seropositivity was associated with immediate memory impairment (OR, 3.26; 95% CI, 1.68-6.32).CONCLUSIONS:
Future studies examining the biological pathways by which herpesviruses influence cognitive impairment across the life course are warranted.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Trastornos del Conocimiento
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Infecciones por Citomegalovirus
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Herpes Simple
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Qualitative_research
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Infect Dis
Año:
2014
Tipo del documento:
Article