Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus.
Nat Immunol
; 15(1): 27-35, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-24317038
ABSTRACT
The generation of T cells depends on the migration of hematopoietic progenitor cells to the thymus throughout life. The identity of the thymus-settling progenitor cells has been a matter of considerable debate. Here we found that thymopoiesis was initiated by a first wave of T cell lineage-restricted progenitor cells with limited capacity for population expansion but accelerated differentiation into mature T cells. They gave rise to αß and γδ T cells that constituted Vγ3(+) dendritic epithelial T cells. Thymopoiesis was subsequently maintained by less-differentiated progenitor cells that retained the potential to develop into B cells and myeloid cells. In that second wave, which started before birth, progenitor cells had high proliferative capacity but delayed differentiation capacity and no longer gave rise to embryonic γδ T cells. Our work reconciles conflicting hypotheses on the nature of thymus-settling progenitor cells.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Timo
/
Células Madre Hematopoyéticas
/
Linfocitos T
/
Diferenciación Celular
Límite:
Animals
Idioma:
En
Revista:
Nat Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2014
Tipo del documento:
Article