Randomized controlled trial on timing and number of sampling for bile aspiration cytology.
J Hepatobiliary Pancreat Sci
; 21(6): 433-8, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24353113
ABSTRACT
BACKGROUND:
The issue on timing and number of bile sampling for exfoliative bile cytology is still unsettled.METHODS:
A total of 100 patients with cholangiocarcinoma undergoing resection after external biliary drainage were randomized into two groups a 2-day group where bile was sampled five times per day for 2 days; and a 10-day group where bile was sampled once per day for 10 days (registered University Hospital Medical Information Network/ID 000005983). The outcome of 87 patients who underwent laparotomy was analyzed, 44 in the 2-day group and 43 in the 10-day group.RESULTS:
There were no significant differences in patient characteristics between the two groups. Positivity after one sampling session was significantly lower in the 2-day group than in the 10-day group (17.0 ± 3.7% vs. 20.7 ± 3.5%, P = 0.034). However, cumulative positivity curves were similar and overlapped each other between both groups. The final cumulative positivity by the 10th sampling session was 52.3% in the 2-day group and 51.2% in the 10-day group. We observed a small increase in cumulative positivity after the 5th or 6th session in both groups.CONCLUSIONS:
Bile cytology positivity is unlikely to be affected by sample time.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Bilis
/
Neoplasias de los Conductos Biliares
/
Conductos Biliares Intrahepáticos
/
Drenaje
/
Colangiocarcinoma
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Hepatobiliary Pancreat Sci
Año:
2014
Tipo del documento:
Article
País de afiliación:
Japón