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Benzimidazole CB2 agonists: design, synthesis and SAR.
Nanda, Kausik K; Henze, Darrell A; Della Penna, Kimberly; Desai, Reshma; Leitl, Michael; Lemaire, Wei; White, Rebecca B; Yeh, Suzie; Brouillette, Janine N; Hartman, George D; Bilodeau, Mark T; Trotter, B Wesley.
Afiliación
  • Nanda KK; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, United States. Electronic address: kausik_nanda@merck.com.
  • Henze DA; Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
  • Della Penna K; Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
  • Desai R; Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
  • Leitl M; Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
  • Lemaire W; Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
  • White RB; Department of Drug Metabolism & Pharmacokinetics, Merck Research Laboratories, West Point, PA, United States.
  • Yeh S; Department of Drug Metabolism & Pharmacokinetics, Merck Research Laboratories, West Point, PA, United States.
  • Brouillette JN; Department of Structure Elucidation, Merck Research Laboratories, West Point, PA, United States.
  • Hartman GD; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, United States.
  • Bilodeau MT; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, United States.
  • Trotter BW; Department of Medicinal Chemistry, Merck Research Laboratories, Boston, MA, United States.
Bioorg Med Chem Lett ; 24(4): 1218-21, 2014 Feb 15.
Article en En | MEDLINE | ID: mdl-24461289
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bencimidazoles / Diseño de Fármacos / Receptor Cannabinoide CB2 Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bencimidazoles / Diseño de Fármacos / Receptor Cannabinoide CB2 Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article