Association between single nucleotide polymorphism rs1044925 and the risk of coronary artery disease and ischemic stroke.
Int J Mol Sci
; 15(3): 3546-59, 2014 Feb 26.
Article
en En
| MEDLINE
| ID: mdl-24577316
ABSTRACT
The present study was performed to clarify the association between the acyl-CoAcholesterol acyltransferase-1 (ACAT-1) single nucleotide polymorphism (SNP) rs1044925 and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Guangxi Han population. Polymerase chain reaction and restriction fragment length polymorphism was performed to determine the genotypes of the ACAT-1 SNP rs1044925 in 1730 unrelated subjects (CAD, 587; IS, 555; and healthy controls; 588). The genotypic and allelic frequencies of rs1044925 were significantly different between the CAD patients and controls (p = 0.015) and borderline different between the IS patients and controls (p = 0.05). The AC/CC genotypes and C allele were associated with a decreased risk of CAD and IS (CAD p = 0.014 for AC/CC vs. AA, p = 0.022 for C vs. A; IS p = 0.014 for AC/CC vs. AA; p = 0.017 for C vs. A). The AC/CC genotypes in the healthy controls, but not in CAD or IS patients, were associated with an increased serum high-density lipoprotein cholesterol (HDL-C) concentration. The present study shows that the C allele carriers of ACAT-1 rs1044925 were associated with an increased serum HDL-C level in the healthy controls and decreased risk in CAD and IS patients.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Acetil-CoA C-Acetiltransferasa
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Enfermedad de la Arteria Coronaria
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Predisposición Genética a la Enfermedad
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Accidente Cerebrovascular
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Polimorfismo de Nucleótido Simple
Tipo de estudio:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Int J Mol Sci
Año:
2014
Tipo del documento:
Article
País de afiliación:
China