Assessment of hemostaseologic alterations induced by hyperbaric oxygen therapy using point-of-care analyzers.
Undersea Hyperb Med
; 41(1): 17-26, 2014.
Article
en En
| MEDLINE
| ID: mdl-24649713
ABSTRACT
BACKGROUND:
Exposure to hyperbaric conditions influences the coagulation system. Thromboembolic events and disseminated intravascular coagulation were observed.OBJECTIVES:
To detect the effects of a hyperbaric environment on the human coagulation system using the point-of-care coagulation analyzers Multiplate and ROTEM. PATIENTS/METHODS:
20 patients were included. Each received 90 minutes of oxygen intermittently at 2.4 atmospheres absolute, as per the TS 240-90 wound-healing protocol. Blood samples were taken before and after hyperbaric exposure and ROTEM, Multiplate and standard laboratory assays were subsequently performed.RESULTS:
ROTEM showed a significant increase of the maximum clot firmness (EXTEM MCF; p < 0.05) and the thromboelastometric platelet component of the clot firmness (MCF(EXTEM) - MCF(FIBTEM); p < 0.01). Multiplate showed a platelet activation mediated by thrombin (AU TRAP-test; p < 0.05) and by arachidonic acid (AUC ASPI-test; p < 0.01). Standard laboratory assays revealed a lower activated partial thromboplastin time (p < 0.05) and a higher leukocyte count (p < 0.05). No further changes were detected. A t-test was performed after testing if data followed normal distribution.CONCLUSIONS:
ROTEM and Multiplate were able to detect an activation of platelets after HBO2 therapy via thrombin and arachidonic acid pathways. Previously reported fibrinolysis could not be confirmed.
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Bases de datos:
MEDLINE
Asunto principal:
Tromboelastografía
/
Coagulación Sanguínea
/
Activación Plaquetaria
/
Sistemas de Atención de Punto
/
Oxigenoterapia Hiperbárica
Tipo de estudio:
Guideline
/
Prognostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Undersea Hyperb Med
Asunto de la revista:
FISIOLOGIA
Año:
2014
Tipo del documento:
Article