Cytotoxic constituents from Lobaria scrobiculata and a comparison of two bioassays for their evaluation.
J Nat Prod
; 77(4): 1069-73, 2014 Apr 25.
Article
en En
| MEDLINE
| ID: mdl-24725159
ABSTRACT
Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fenoles
/
Benzofuranos
/
Líquenes
/
Antineoplásicos Fitogénicos
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Nat Prod
Año:
2014
Tipo del documento:
Article
País de afiliación:
Austria