Skin-homing Th2/Th22 cells in papuloerythroderma of Ofuji.
Dermatology
; 228(4): 326-31, 2014.
Article
en En
| MEDLINE
| ID: mdl-24732450
ABSTRACT
Papuloerythroderma of Ofuji (PEO) appears to be a T cell-mediated skin disease; however, the pathogenesis of PEO remains unclear. We report two cases of PEO and examine cytokine production and expression of skin-homing receptors in circulating T cells in the patients. The percentages of interleukin 4 (IL-4)-, IL-13- and IL-22-producing CD4+ and CD8+ T cells were markedly higher in the circulation of patients with PEO than in those of healthy subjects. The expression of both cutaneous lymphocyte antigen (CLA) and CC chemokine receptor 4 (CCR4) were significantly upregulated in the circulating CD4+ and CD8+ T cells. Moreover, serum levels of thymus and activation-regulated chemokine (TARC), a chemoattractant for CCR4, were increased. The number of IL-4-, IL-13- and IL-22-producing T cells, expression of CLA and CCR4 by T cells, and serum TARC levels significantly decreased after complete remission of PEO. These results suggest that skin-homing Th2/Th22 cells may play a role in the pathogenesis of PEO.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Cutáneas Papuloescamosas
/
Dermatitis Exfoliativa
/
Células Th2
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Linfocitos T CD8-positivos
Límite:
Aged
/
Aged80
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Humans
/
Male
Idioma:
En
Revista:
Dermatology
Asunto de la revista:
DERMATOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Japón