Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity.

Flynn, Robyn; Chapman, Kevin; Iftinca, Mircea; Aboushousha, Reem; Varela, Diego; Altier, Christophe

Flynn, Robyn; Chapman, Kevin; Iftinca, Mircea; Aboushousha, Reem; Varela, Diego; Altier, Christophe.

Afiliación

Flynn R; From the Department of Physiology and Pharmacology and Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada and.
Chapman K; From the Department of Physiology and Pharmacology and Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada and.
Iftinca M; From the Department of Physiology and Pharmacology and Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada and.
Aboushousha R; From the Department of Physiology and Pharmacology and Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada and.
Varela D; Centro de Estudios Moleculares de la Celula and Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, 8380453, Chile.
Altier C; From the Department of Physiology and Pharmacology and Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta T2N 4N1, Canada and altier@ucalgary.ca.

J Biol Chem ; 289(24): 16675-87, 2014 Jun 13.

Article en En | MEDLINE | ID: mdl-24808184

Asunto(s)

Hiperalgesia/metabolismo; Multimerización de Proteína; Canales Catiónicos TRPV/metabolismo; Secuencias de Aminoácidos; Animales; Artritis Experimental/metabolismo; Artritis Experimental/fisiopatología; Sitios de Unión; Eliminación de Gen; Células HEK293; Humanos; Inflamación/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Subunidades de Proteína/química; Subunidades de Proteína/genética; Subunidades de Proteína/metabolismo; Transporte de Proteínas; Ratas; Canales Catiónicos TRPV/química; Canales Catiónicos TRPV/genética

Palabras clave

Bioluminescence Resonance Energy Transfer (BRET); Biomolecular Fluorescence Complementation; Pain; Protein Assembly; Site-directed Mutagenesis; Trafficking; Transient Receptor Potential Channels (TRP Channels)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Canales Catiónicos TRPV / Multimerización de Proteína / Hiperalgesia Límite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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