Poroelastic response of articular cartilage by nanoindentation creep tests at different characteristic lengths.
Med Eng Phys
; 36(7): 850-8, 2014 Jul.
Article
en En
| MEDLINE
| ID: mdl-24814573
ABSTRACT
Nanoindentation is an experimental technique which is attracting increasing interests for the mechanical characterization of articular cartilage. In particular, time dependent mechanical responses due to fluid flow through the porous matrix can be quantitatively investigated by nanoindentation experiments at different penetration depths and/or by using different probe sizes. The aim of this paper is to provide a framework for the quantitative interpretation of the poroelastic response of articular cartilage subjected to creep nanoindentation tests. To this purpose, multiload creep tests using spherical indenters have been carried out on saturated samples of mature bovine articular cartilage achieving two main quantitative results. First, the dependence of indentation modulus in the drained state (at equilibrium) on the tip radius a value of 500 kPa has been found using the large tip (400 µm radius) and of 1.7 MPa using the smaller one (25 µm). Secon, the permeability at microscopic scale was estimated at values ranging from 4.5×10(-16) m(4)/N s to 0.1×10(-16) m(4)/N s, from low to high equivalent deformation. Consistently with a poroelastic behavior, the size-dependent response of the indenter displacement disappears when characteristic size and permeability are accounted for. For comparison purposes, the same protocol was applied to intrinsically viscoelastic homogeneous samples of polydimethylsiloxane (PDMS) both indentation modulus and time response have been found size-independent.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cartílago Articular
/
Nanopartículas
/
Modelos Biológicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Med Eng Phys
Asunto de la revista:
BIOFISICA
/
ENGENHARIA BIOMEDICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Italia