Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.

Popovici-Muller, Janeta; Saunders, Jeffrey O; Salituro, Francesco G; Travins, Jeremy M; Yan, Shunqi; Zhao, Fang; Gross, Stefan; Dang, Lenny; Yen, Katharine E; Yang, Hua; Straley, Kimberly S; Jin, Shengfang; Kunii, Kaiko; Fantin, Valeria R; Zhang, Shunan; Pan, Qiongqun; Shi, Derek; Biller, Scott A; Su, Shinsan M

Popovici-Muller, Janeta; Saunders, Jeffrey O; Salituro, Francesco G; Travins, Jeremy M; Yan, Shunqi; Zhao, Fang; Gross, Stefan; Dang, Lenny; Yen, Katharine E; Yang, Hua; Straley, Kimberly S; Jin, Shengfang; Kunii, Kaiko; Fantin, Valeria R; Zhang, Shunan; Pan, Qiongqun; Shi, Derek; Biller, Scott A; Su, Shinsan M.

Afiliación

Popovici-Muller J; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Saunders JO; Ember Therapeutics , 855 Boylston Street, 11th Floor, Suite B, Boston, Massachusetts 02116, United States.
Salituro FG; Sage Therapeutics , 215 First Street, Cambridge, Massachusetts 02141, United States.
Travins JM; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Yan S; Schrödinger, Inc. , 120 West 45th Street, New York, New York 10036, United States.
Zhao F; Sundia MediTech Company, Ltd. , Building 8, 388 Jialilue Road, Zhangjiang High-Tech Park, Shanghai 201203, China.
Gross S; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Dang L; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Yen KE; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Yang H; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Straley KS; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Jin S; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Kunii K; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Fantin VR; Oncology Research Unit, Pfizer Worldwide Research and Development , La Jolla Laboratories, San Diego, California 92121, United States.
Zhang S; Shanghai ChemPartner Co., LTD , 998 Halei Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China.
Pan Q; Shanghai ChemPartner Co., LTD , 998 Halei Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China.
Shi D; Shanghai ChemPartner Co., LTD , 998 Halei Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China.
Biller SA; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.
Su SM; Agios Pharmaceuticals , 38 Sidney Street, Cambridge, Massachusetts 02139, United States.

ACS Med Chem Lett ; 3(10): 850-5, 2012 Oct 11.

Article en En | MEDLINE | ID: mdl-24900389

Palabras clave

Mutant IDH1; R132H IDH1 inhibitors; tumor 2-HG

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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos