An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.

Kuo, Ching-Ying; Li, Xu; Kong, Xiang-Qian; Luo, Cheng; Chang, Che-Chang; Chung, Yiyin; Shih, Hsiu-Ming; Li, Keqin Kathy; Ann, David K

Kuo, Ching-Ying; Li, Xu; Kong, Xiang-Qian; Luo, Cheng; Chang, Che-Chang; Chung, Yiyin; Shih, Hsiu-Ming; Li, Keqin Kathy; Ann, David K.

Afiliación

Kuo CY; From the Department of Molecular Pharmacology and Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, California 91010.
Li X; From the Department of Molecular Pharmacology and.
Kong XQ; the Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Luo C; the Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
Chang CC; the Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, and.
Chung Y; From the Department of Molecular Pharmacology and.
Shih HM; the Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, and.
Li KK; the State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, 197 Ruijin II Road, Shanghai 200025, China kli@epigenetic.us.
Ann DK; From the Department of Molecular Pharmacology and Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, California 91010, dann@coh.org.

J Biol Chem ; 289(30): 20757-72, 2014 Jul 25.

Article en En | MEDLINE | ID: mdl-24907272

Asunto(s)

Daño del ADN; Proteínas Nucleares/metabolismo; Proteolisis; Proteína SUMO-1/metabolismo; Sumoilación/fisiología; Factores de Transcripción/metabolismo; Secuencias de Aminoácidos; Células HEK293; Células HeLa; Humanos; Proteínas Nucleares/genética; Proteínas Represoras/genética; Proteína SUMO-1/genética; Factores de Transcripción/genética; Proteína 28 que Contiene Motivos Tripartito

Palabras clave

ATM; Arginine-rich Motif; DNA Damage Response; KAP1; Phosphorylation; Protein-Protein Interaction; RNF4; STUbL; SUMOylation; Ubiquitylation (Ubiquitination)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Factores de Transcripción / Daño del ADN / Proteínas Nucleares / Proteína SUMO-1 / Sumoilación / Proteolisis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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