Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry.

Lee, Susan; Braun, Craig R; Bird, Gregory H; Walensky, Loren D

Lee, Susan; Braun, Craig R; Bird, Gregory H; Walensky, Loren D.

Afiliación

Lee S; Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.
Braun CR; Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA; Department of Cell Biology, Harvard Medical School, B
Bird GH; Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.
Walensky LD; Department of Pediatric Oncology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: loren_walensky@dfci.harvard.edu.

Methods Enzymol ; 544: 25-48, 2014.

Article en En | MEDLINE | ID: mdl-24974285

Asunto(s)

Espectrometría de Masas/métodos; Péptidos/metabolismo; Fármacos Fotosensibilizantes/metabolismo; Mapeo de Interacción de Proteínas/métodos; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Secuencia de Aminoácidos; Animales; Apoptosis; Sitios de Unión; Humanos; Modelos Moleculares; Datos de Secuencia Molecular; Péptidos/análisis; Fármacos Fotosensibilizantes/análisis; Estructura Secundaria de Proteína; Estructura Terciaria de Proteína; Proteómica; Proteínas Proto-Oncogénicas c-bcl-2/análisis

Palabras clave

Apoptosis; BAD; BAK; BAX; BCL-2 family; BCL-XL; BH3; BID; BIM; Binding site; Glucokinase; MCL-1; Mass spectrometry; PUMA; Photoaffinity labeling; Photoreactive; Protein interaction; Stabilized Alpha-Helix (SAH); Stabilized Alpha-Helix of BCL-2 domain (SAHB); Stapled peptide

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Espectrometría de Masas / Fármacos Fotosensibilizantes / Proteínas Proto-Oncogénicas c-bcl-2 / Mapeo de Interacción de Proteínas Límite: Animals / Humans Idioma: En Revista: Methods Enzymol Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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