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Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain.
Moreno-Sanz, Guillermo; Barrera, Borja; Armirotti, Andrea; Bertozzi, Sine M; Scarpelli, Rita; Bandiera, Tiziano; Prieto, Julio G; Duranti, Andrea; Tarzia, Giorgio; Merino, Gracia; Piomelli, Daniele.
Afiliación
  • Moreno-Sanz G; Department of Anatomy and Neurobiology, University of California, Irvine 92697-4621, USA.
  • Barrera B; INDEGSAL, Campus Vegazana s/n, University of Leon, 24071 Leon, Spain; Department of Biomedical Sciences - Physiology, Veterinary Faculty, Campus Vegazana s/n, University of Leon, 24071 Leon, Spain.
  • Armirotti A; Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, via Morego 30, I-16163 Genova, Italy.
  • Bertozzi SM; Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, via Morego 30, I-16163 Genova, Italy.
  • Scarpelli R; Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, via Morego 30, I-16163 Genova, Italy.
  • Bandiera T; Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, via Morego 30, I-16163 Genova, Italy.
  • Prieto JG; Department of Biomedical Sciences - Physiology, Veterinary Faculty, Campus Vegazana s/n, University of Leon, 24071 Leon, Spain.
  • Duranti A; Dipartimento di Scienze Biomolecolari, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, I-61029 Urbino, Italy.
  • Tarzia G; Dipartimento di Scienze Biomolecolari, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, I-61029 Urbino, Italy.
  • Merino G; INDEGSAL, Campus Vegazana s/n, University of Leon, 24071 Leon, Spain; Department of Biomedical Sciences - Physiology, Veterinary Faculty, Campus Vegazana s/n, University of Leon, 24071 Leon, Spain.
  • Piomelli D; Department of Anatomy and Neurobiology, University of California, Irvine 92697-4621, USA; Drug Discovery and Development, Fondazione Istituto Italiano di Tecnologia, via Morego 30, I-16163 Genova, Italy. Electronic address: piomelli@uci.edu.
Pharmacol Res ; 87: 87-93, 2014 Sep.
Article en En | MEDLINE | ID: mdl-24993496
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cannabinoides / Carbamatos / Transportadoras de Casetes de Unión a ATP / Amidohidrolasas Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cannabinoides / Carbamatos / Transportadoras de Casetes de Unión a ATP / Amidohidrolasas Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos