Aging of the human innate immune system in HIV infection.
Curr Opin Immunol
; 29: 127-36, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-24997358
ABSTRACT
HIV infection is associated with a chronic inflammatory state arising from multiple factors, including innate immune recognition of HIV, increased microbial translocation, and release of endogenous ligands from damaged cells (such as CD4 T cells). In many respects, this heightened pro-inflammatory environment resembles that associated with aging in the absence of HIV infection, and evidence of dysregulated innate immune responses can be found in not only older HIV-negative adults, but also adults with HIV infection. While the study of innate immune aging in HIV infection is still in its early stages, it seems likely that at least additive, or potentially synergistic effects of aging and HIV infection will be found.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Infecciones por VIH
/
Inmunidad Innata
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos